Superoxide reductase

src: genomics.unl.edu

Superoxide reductase is an enzyme that catalyzes the conversion of highly reactive and toxic superoxide (O₂^-) into less toxic hydrogen peroxide (H₂O₂):

reduced rubredoxin + O₂^- + 2 H⁺ ${\displaystyle \rightleftharpoons }$ rubredoxin + H₂O₂

Fe²⁺ + O₂^- + 2 H⁺ ${\displaystyle \rightleftharpoons }$ Fe³⁺+ H₂O₂

Hydrogen peroxide in turn is reduced to water by rubrerythrin. The 3 substrates of this enzyme are reduced rubredoxin, superoxide, and H⁺, whereas its two products are rubredoxin and H₂O₂.

This enzyme belongs to the family of oxidoreductases, specifically those acting on superoxide as acceptor (only sub-subclass identified to date). The systematic name of this enzyme class is rubredoxin:superoxide oxidoreductase. Other names in common use include neelaredoxin, and desulfoferrodoxin.

Video Superoxide reductase

Structural studies

As of late 2007, 9 structures have been solved for this class of enzymes, with PDB accession codes 1VZG, 1VZH, 1VZI, 1Y07, 2AMU, 2HVB, 2JI1, 2JI2, and 2JI3.

Maps Superoxide reductase

References

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Further reading

Source of the article : Wikipedia